In particular, contents of PANI-LSA are quite small, and therefore, quantities of the plasticizing dopant LSA are not enough to significantly weaken interactions between PS macromolecules.
It is caused by specific mutations in gyrase and topoisomerase IV that weaken interactions between quinolones and these enzymes.
It thus appears that the mutation may weaken interactions with ubiquitin required for substrate recognition and/or catalysis.
Moreover, degradation rates of ATP-GLK and ADP-GLK in T. tengcongensis were evaluated, indicating that ATP-GLK was unstable due to weaken interactions with HSP60 at 80°C.
We speculate that binding of ITC metabolites to the allosteric site weaken interactions between HDAC3 and SMRT, which facilitates complex dissociation and GCN5 (HAT) recruitment on CtIP.
In contrast, inhibitors that stabilize helix αC in an active conformation weaken interactions between the SH2/SH3 domains and their respective intramolecular ligands.
Lfng and Mfng preserve and possibly strengthen interactions between Notch1 and Dll1, in cis and in trans, and weaken interactions between Notch1 and Jag1, in cis and in trans, while Rfng preserves or enhances the cis interactions with both ligands.
Another mutation, eIF2Bβ-V316D (not visible in Figure 6B), affects a residue buried just under the predicted eIF2Bδ-binding surface of eIF2Bβ and was reported to weaken interactions with the rest of eIF2B.
Intriguingly, the phosphoinositide PtdIns(4,5 P2 (which is critical for endocytosis; see Vesicle Scission and Uncoating) can weaken interactions between CP and barbed ends in other systems (Schafer et al. 1996).
Phosphorylation of Bcl-2 and Bcl-xL during mitotic arrest, on the other hand, does not affect protein expression levels but does appear to weaken interactions with pro-apoptotic Bcl-2 proteins such as Bax.
