Accordingly, some mitotic chromosomes were said to have displayed weakened cohesion between sisters.
Surprisingly, although many cells required Esco2 to establish cohesion, 10-20% of cells had only weakened cohesion in the absence of Esco2, suggesting that compensatory cohesion mechanisms exist in these cells that undergo a normal mitotic division.
These observations suggest that there are two pools of mutant cells: (1) cells with complete cohesion loss, separated chromatids, and high aneuploidy biasing toward loss of chromatids; and (2) weakened cohesion, PBS chromatids, and none to mild aneuploidy with equivalent gains and losses.
This will exacerbate the legitimacy problems of markets, weaken social cohesion and undermine political effectiveness.
Even more damagingly, she has framed her argument in terms that are far more likely to weaken social cohesion than to strengthen it.
This was likely to increase herding labour in future, weaken community cohesion and increase agitation for land subdivision into freehold as noted elsewhere in the country (Mwangi 2005; Sundstrom et al. 2012).
But it appears that the loss of safety Kenny Phillips to season-ending knee surgery has weakened the cohesion of the secondary.
They also attacked Walpole's foreign policy, but when the tide was turning against Walpole, Wyndham's death in 1740 weakened the cohesion of the combined opposition.
His crucial passage points out that diversity and variety are good – the curry-house argument – but they come with a price tag: weakened social cohesion, which makes voters less willing to support generous welfare payments.
However, internal disputes between the "realists" (Realos), who took a pragmatic approach to environmental policies, and the "fundamentalists" (Fundis), who eschewed compromise in favour of ideological purity, and dissension over individual issues weakened the cohesion of the party's constituent factions.
