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Clearly, no information is gathered about binding location or target affinity and, taken in isolation, a small thermal shift is very weak validation of a hit.
With respect to the most recently proposed pathway of cassava starch biosynthesis [ 21], which contained less confident annotation with weak validation process, the contribution of this work provides a higher-quality pathway of starch biosynthesis in cassava.
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This is the weakest validation protocol.
The small number of cases and weaker validation limits the clinical application of their result.
The marginal difference in ratio of affected to unaffected individuals in high versus low risk groups explains the weak cross-validation metric (CVC) value of 4/10, confirming that the study population was obviously too small to identify shared genetic interacting loci with small effects with the MDR approach.
Predictive performance for PM10 2.5 was weaker (cross-validation R = 0.39) with lower precision (5.5 μg/m).
The validation weak sign increased recycling more than the validation strong sign, especially after the signs were removed.
What will validation validate?
Although the response of WEE1-3'-UTR in our target gene validation assay was weaker than that of CCND1 or RBL2, this finding further demonstrates, that miR-17, -20a, and -106b can potentially act as pro-proliferative microRNAs in a coordinated manner at different regulatory checkpoints of the cell cycle.
There are many reports of plasma-Pb measurements where validation data are either weak or absent.
The validation studies were methodologically weak and heterogeneous, making it questionable to compare the case definitions.
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CEO of Professional Science Editing for Scientists @ prosciediting.com