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In a cross-sectional network model on depression symptoms, Schweren and colleagues29 did not detect a significant difference in the global network strength between strong- and weak treatment responders.
Weak treatment policies that allow non-compliance, select against drug-susceptible TB and permit resistance to emerge, but they only give MDR-TB a foothold when most of the population has not had a prior infection with TB.
The interaction term had a p value of 0.12, which using a more relaxed threshold p value (<0.2), suggested there could be a weak treatment effect for EOD patients.
Gene expression could be influenced by secondary effects (e.g. apoptosis or necrosis) if the treatment was too severe, whilst too weak treatment might not trigger the expression of some of the rhizotoxin-sensitive genes.
Fisher's method assigns a disproportionate weight to very small p-values, which can lead to a significant overall p-value, even when most p-values being combined suggest a weak treatment effect.
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Overall, the medications looked best for very severe depression and had only slight benefits for mild depression — but this study, looking at weak treatments and intentionally maximized placebo effects, could not quite meet the scientific standard for a firm conclusion.
Under weak treatments, the non-resistant plasmids outcompete plasmids carrying the resistance gene due to the costs c p of expressing the resistance gene.
Some gains were lost at the 1- and 3-month follow-up, particularly for the participants who showed weaker treatment responses.
In certain situations subgroups with weaker treatment effects on relative risk may have the greater potential benefit in terms of absolute risk.
In any case, CR was compared with an active intervention although with lower duration and intensity, and not a weaker treatment condition such as treatment as usual or waiting list.
A recently published 24-week trial that also evaluated moderate to severe AD patients suggested a weaker treatment effect with memantine monotherapy; treatment was not associated with significant overall cognitive or global changes in this trial, although there were apparent benefits at intermediate time points [ 21].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com