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The basic idea is that we first generate an ensemble of weak translation systems using a base learning algorithm, and then learn a strong translation system from the ensemble.
The weak translation of these latter proteins suggests that their presence could be largely strain dependent (Ou et al. 2005).
Caenorhabditis elegans genes with a large number of exons, short exons, long introns, a weak translation start signal, weak splice sites or poorly conserved orthologs pose great difficulty for gene prediction programs (Williams,G.W. and Davis,P.A., personal observation).
Recent work has demonstrated that ribosome footprints on noncoding RNAs and noncoding regions of mRNAs (such as the 5′ UTR) can be discriminated from translation of functional protein-coding genes because the profile does not terminate at stop codons, likely due to the presence of weak translation in multiple overlapping reading frames [ 38, 39].
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The novel rocaglates identified in this study are overall weaker translation inhibitors as compared to RHT and silvestrol, the later being known as powerful inhibitors of translation which are cytotoxic to leukemic cells.
This decreased binding affinity correlates well with our E. coli translation inhibition study which showed peptolide 12g has the weakest translation inhibition activity (IC50 value of 60 μM, Table 1).
With the exception of K176A, which displayed only weak translational competence, non-conservative substitutions to all other residues involved in cap-binding abolished translation in yeast (Table 1).
The company's revenue would have grown 13 percent without the weak currency translations.
Those who either lived in Connecticut or spent extensive periods there included Childe Hassam, Julian Alden Weir, John Twachtman, Theodore Robinson and Willard Metcalf, but there were plenty of lesser-knowns as well as later also-rans who produced weak American translations of the work of their French predecessors.
This apparent paradox suggests either that a weak inhibition of translation is more effective for longevity or that rapamycin can extend lifespan by mechanisms other than translation.
Throw in weak exports, currency translation losses for U.S. multinationals, and run it all up against tight labor markets, and you have big-time pressure on corporate earnings.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com