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Rugged folding landscapes result as a consequence of the need to form the thousands of weak, stabilising interactions which are present in the native state (reviewed in Ref. [31]).
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But the inability of Ins(1,4 P2 to mobilise Ca2+ or bind to IP3R suggests that interaction of P-1 alone with the α-domain, where it directly contacts only Arg568 (R568, Fig. 2), is too weak to stabilise binding.
One rationale for this observation, is as the loop length increases, the structure gains more flexibility, and therefore stabilising interactions become weaker.
"The multi-stimulus of cheap oil, a weak euro and aggressive monetary easing is now stabilising expectations and will help the ECB reach its price stability target over time".
Carney said the Bank's nine-member monetary policy committee, which sets interest rates, faces a trade-off between stabilising inflation, which could be stoked by a weaker pound, and shoring up growth and jobs.
Government unemployment benefits keep up living standards among the jobless, and so help stabilise a weak economy by bolstering consumer demand.
This mechanism involves the formation of a small nucleus of structure stabilised by weak, possibly long-range, contacts and the subsequent rapid collapse around this folding nucleus to yield the native state [10,12,15].
But they say that he has performed well above his usual poll rating, stabilising his position and undermining Tory attempts to portray him as weak.
Things appeared to be stabilising.
Let alone stabilising the economy".
The euro zone seems to be stabilising.
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