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It should also be noted that when the selective pressure is weak (simulation B), the time until the fixation of the advantageous allele is greater than it would be in the case of a strong selection pressure (simulation C).
In order to assess bias when IVs are weak (simulation 3), we varied the n X: n Y ratio from 0.1 (a small subsample) to 1.0 (the complete-data scenario) and varied the average first-stage F statistic from approximately 1 to approximately 20, with β XY set to 0.1.
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On the other hand, the empirical equations proposed in this context generally produce weak simulations, except when a local calibration is used for improving their performance.
In this paper, we propose a weaker simulation over structures called forced simulation for automated debugging.
A simulation showing weak model separation according to the highest dose scheme can be seen in Additional file 1: Figure S2.
a Weak selection (simulation B) and b strong selection (simulation C).
In the case of good or satisfactory results, the plan should be modified by the features pointed out as missing or weak in simulation and testing process.
While those estimators have desirable asymptotic properties under weak regularity conditions, simulation studies have shown these estimators to exhibit a small sample bias in the opposite direction of the least squares bias for censored data.
Negative epistasis (e.g. genes are part of parallel pathways) is relatively weak throughout the simulation.
In our simulations, a weak proliferative advantage (selection model parameter = 0.0059, selection model with cell death value = 0.011) was sufficient to drive the clonal expansion and account for the mutant clusters seen in the 80-year-old male we studied.
These differences will likely have an impact on sound generation; the acoustic pressure field will be higher and the second harmonic will be dominant in contrast to the weaker fully-coupled simulation.
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