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If large changes in the Raf-1-P amplitudes are observed for perturbations in the MKP-3 concentrations, one can infer that the system has weak sequestration.
In conclusion, our model predicts sequestration primarily of PIP2 lipids by the adsorbing basic peptide, and very weak sequestration of PS lipids.
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But mostly the plot shows very weak PS sequestration compared to that seen for PIP2.
But biogeochemist Jorge Sarmiento of Princeton University says that because carbon measurements in the study varied so widely, the data are "weaker proof [of iron-enhanced carbon sequestration] than I think we would have liked".
However NTS-DBL1α domain of the VARO PfEMP1 that is not involved in the placental sequestration of parasites also presented a weak affinity to CSPG.
Binding to the endothelial receptor ICAM-1 has been associated with sequestration in brain vasculature [5] and showed a weak but not statistically significant association in one study with cerebral malaria (CM), while adhesion to CD36 showed no association [6].
The lysosomal sequestration of sunitinib, which is a result of its weak basic feature, and its accumulation, due to the protonation of the molecule inside the lysosome, is not unique to sunitinib.
The EU's commitment will be accomplished largely through weak or unrealistic containment measures like carbon trading or techno-fixes like carbon sequestration and storage, not by moderating economic growth or reducing consumption.
Our results show that the hydrophobic cluster that forms in p63 "slows" down folding but yet eventually does lead to a conformation that is suitable for sequestration by MDM2; this may partly be responsible for the experimental demonstrations of weak interaction between p63 and MDM2 (relative to the interactions between MDM2 and p53/p73).
This result suggests that weaker binding (and larger dissociation constants) promoted fewer off-target effects, as would be expected given the decreased sequestration of Y3* that would occur.
Furthermore, there is some evidence that Bcl-2 is a much weaker pro-survival factor than, for instance, Bcl-xL and work with mouse embryonic fibroblasts has revealed that sequestration of Bcl-xL and Mcl-1 is sufficient to induce apoptosis.
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