This also requires authors to give a more appropriate interpretation of results in light of power estimates since genetic effects are expected to be weak and sample sizes will rarely increase to the extent considered necessary [ 52].
Moreover, it proves useful for identifying genomic markers with a common effect across multiple genomic studies due to its weak dependence on sample size variations.
The lack of a significant relation between the other potential explanatory variables and T-PAH concentration does not necessarily mean there is no relation but rather might arise because that relation is relatively weak and the sample size relatively small.
Most of the standardized regression coefficients were either weak or very weak, and the large sample size increased the risk of a Type I error when testing each coefficient's statistical significance.
In GWA studies, one of the main challenges is to detect SNPs having weak signals with limited sample size.
Protein expression in luminal A tumors was lower than in luminal B tumors and thus the correlation between mRNA and protein may be weak and a larger sample size would be necessary to observe a positive correlation.
Although we did have OTA occurrence data for most of the major foods known to be susceptible to OTA contamination, for some commodities the data set was considered weak due to small sample size (e.g. rice, beer), while for others, the data set was excluded from the assessment due to very small sample size (e.g. corn, rye) or lack of data (e.g. human breast milk, cocoa products, spices).
The other paediatric study found a weaker association, although the sample size was much smaller, with only 16 cases with SLE and 20 controls [ 34].
It has to be admit that the study design and sample size is weak to draw general conclusions.
Finally, although our aim was to compare groups of patients with various degrees of OSA, the lack of a control population and the relatively small sample size remain weak points.
