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Brk appears to be a weak negative regulator of AKT in some cell contexts [ 24, 33].
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Some mlo alleles are weak negative regulators such that the plant constitutively expresses parts of the disease resistance pathway, leading to spontaneous cell-death that resembles HR [ 47].
Conversely, the negative regulator GSK3β was down-regulated.
Members of the eye specification network (eyes absent and eyegone) can repress Wnt expression [34] thereby eliminating one negative regulator or eye development [23], [24] within the transdetermination weak points.
Co-expression of the JNK phosphatase puckered (puc), a negative regulator of JNK signalling, had a similar, albeit weaker effect (data not shown).
Myostatin (MSTN) is a negative regulator of skeletal muscle mass.
Spl11 encodes an E3 ubiquitin ligase that functions as a negative regulator of programmed cell death.
OsMKP1 has been shown to be a negative regulator of the wound response in rice.
MiR-142-3p walsolso identified as a key negative regulator of IL-6.
These studies also indicated that SUB1A-1 might be a negative regulator of OsSUB1C.
These findings identified miR-33a as a negative regulator of breast cancer cell proliferation and metastasis.
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