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Sequence analysis [ 37, 38]of editing sites revealed a number of weak motifs.
Remark: recognizability scores obtained by the metrics are compared between strong and weak motifs.
Results show that MISCORE noticeably outperforms MAP score and performs comparably to IC in recognizing weak motifs.
The results show that MISCORE can noticeably outperform MAP score and perform comparably to IC in recognizing weak motifs.
However, the localized-MISCORE is likely to be more effective in recognizing weak motifs than IC and MAP score.
Nowadays, identifying weak motifs and reducing the effect of local optimum are still important but challenging tasks for motif discovery.
Similar(49)
Our results showed a large increase in the MAF of rs11165878, perhaps due to a lesser binding efficiency of the G allele to the spliceosome, which may cause an increased rate of intron retention in an already weak motif coupled with a relatively weak PPT (45% pyrimidine).
Weak motif characterization and recognition is challenging to all evaluation metrics.
For this our test set contained 8,375 p63 bound locations that had at least a weak p63 motif (score greater than 2.24) and the background set contained 515,933 unbound genomic sites (containing a weak motif).
Thus accessible sites with a strong or weak motif are more accessible and have higher deposition of H3K4me1 than sites lacking a p63 motif.
We likewise find the lipocalin motif; it is a weak motif with few generally conserved residues that is in perfect correspondence with the known lipocalin signature.
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