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Of these, we found that one mutant strain carrying a deletion resulting in the removal of several miRNAs led to a weak lifespan extension.
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The mir-80 allele nDf53 had a weak but significantly extended lifespan (Supplemental Table 3), while the mir-228(n4382) mutant trended towards an extended lifespan (Supplemental Table 3).
gBGC is expected to occur predominantly in recombination hotspots with short lifespans and weak influences on substitution rate, suggesting that it could affect the evolution of base composition in Mb-long genomic fragments, but not individual hotspots (typically 2 kb long) [ 13, 27].
It never affected land until the very end of its lifespan as a weak extratropical system, which had minor impact in the northern British Isles.
Although the dispersal of mayflies is thought to be limited to nearby water bodies because they are weak fliers with short adult lifespans [ 3], it has been shown that long-distance dispersal is more prevalent than previously thought [ 65].
In the article, Murthy noted that loneliness and weak social connections are associated with reduced lifespan and a greater risk for illnesses such as cardiovascular disease, dementia, depression and anxiety.
As reviewed by Blagosklonny, a weak stress such as calorie restriction prolongs lifespan and delays the occurrence of age-related metabolic disorders.
These theories predict that the most-fit individuals remain at the end of the maximum lifespan of an organism, the weak having succumbed to disease, trauma or stochastic events.
Additionally, the rest-activity rhythm becomes weaker and more fragmented over the adult lifespan [ 12].
Although the increase of lifespan in strain SC5314 seems weaker than that in strain BWP17 or S. cerevisiae, the calorie-restriction effect in strain SC5314 is significant because the p-value is less than 0.05.
The weak positive genetic correlation between male and female lifespan is consistent with the results of a previous selection experiment [36].
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