Sentence examples for weak deleterious from inspiring English sources

The difference of the two ratios in D1is therefore expected to equal zero in the absence of weak deleterious effects and large values are indicative of a high frequency of weak deleterious mutations, which results in susceptibility to hitch-hiking.

If weak deleterious effects are rare, then we expect that most deleterious mutations are immediately removed from the population.

Together, these data are consistent with the dominance model of heterosis, in which complementation of numerous low-frequency, weak deleterious variants contribute to hybrid vigor.

D1signals the presence of weak deleterious mutations that can potentially cause hitch-hiking and is based on identifying an excess of non-synonymous low-frequency polymorphisms.

Similarly, the extent of hitch-hiking is controlled by the proportion of sites with weak deleterious effects relative to the strength of positive selection, with the specific range varying according to the strength and prevalence of positive selection.

However, when the fitness cost of halving gene dose per se is small, that is, when pathways are long and selection is weak, deleterious mutations can contribute a substantial proportion of the total fitness cost.

Accordingly, while we may have sampled a few SCPs with large fitness effects, an appreciable proportion of SCPs should be under weaker selection and are only weakly deleterious (Nes ∼ 1).

Gene loss and rate variation in the close group also have remarkably weaker deleterious effects on precision of HGTector than that of conventional BLAST based methods under the D > C scenario (Additional file 1: Figure S8B, C).

The positive correlation between MAF and CADD score of SNPs for which the minor alleles are ancestral may be interpreted by purifying selection: only the alleles with the weakest deleterious effect can drift to a high frequency (a low ancestral allele frequency) in human populations.

Hybrid vigor hypothesizes that crossbred plants, animals, and humans are genetically superior to their parents, since weak, undesirable, deleterious, recessive genes, which might be harmful, are suppressed.

R. philippinarum spermatozoa carry only four mitochondria (Milani et al. 2011), corresponding to a few dozen mtDNAs (Ghiselli et al. 2011), thus the buffering effect is much weaker, and deleterious mutations are more exposed to selection.