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Following the recommendations of the Venice guidelines [22], the association was therefore assigned weak credibility.
Although we did not identify a significant source of bias, the high heterogeneity again confers weak credibility.
This will help us understand whether some types of associations can change from having weak credibility to having strong credibility (and vice versa).
However, the meta-analysis included a low total sample of participants with the minor allele (n = 71), and accordingly, the association was assigned weak credibility.
The other statistically significant pooled associations were assigned weak credibility, either because of low sample sizes, high heterogeneity, or unaccounted sources of bias.
The proposed scheme allows for 3 categories of descending credibility (A, B, C) for each of these criteria and also for a composite assessment of "strong," "moderate," or "weak" credibility (see Appendix Table and Ioannidis et al. (18) for more details).
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Again, this confers weak epidemiological credibility.
A priori all nonsignificant pooled estimates were assigned weak epidemiological credibility.
With high risk of bias the Venice grading was CBC, or weak epidemiological credibility (Table 2).
Following the Venice recommendations, we a priori assigned all nominally significant but unreplicated associations weak epidemiological credibility.
"The question is whether governments should relent in their efforts to reduce deficits now, when the global economy is still weak, and policy credibility is far from granted," the economist Giancarlo Corsetti said in a debate on the VoxEU Web site.
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