We show that wild-type P450 BM3 has activity and weak affinity for substrates as short as butyrate (C4).
The steady-shear viscosity, dynamic viscoelasticity, and normal stress behavior were measured for suspensions flocculated by reversible bridging of polymer with weak affinity for the particle surface.
However, residues 48-74 are not sufficient for high-affinity binding; residues 75-163 alone display weak affinity for TIP47, yet they contribute to the presentation of residues 48-74 in the intact protein.
HwTx-IV and mHwTx-IV exhibited weak affinity for lipid membranes, whereas gHwTx-IV showed improved affinity for the model membranes studied.
This drug displays a weak affinity for the μ and δ-opioid receptors, and weaker affinity for the κ-subtype; it also interferes with the neuronal release and reuptake of serotonin and noradrenaline in the descending inhibitory pathways.
At 100 μM, all compounds exhibited a weak affinity for NRP-1, the most efficient being the bis-guanidinylated compound 32 (IC50 = 92 μM) which could be considered as a new NRP-1 non-peptidic ligand.
Experimental studies indicate that under molecular crowding conditions (in the presence of 40 wt% PEG 200), 1 2 show weak affinity for c-myc, while 3 still displays high affinity and selectivity for c-myc.
The ARG SH2 domain exhibited relatively weak affinity for BCR and was determined to bind about 10-fold less strongly than the ABL SH2 domain.
Initially the primary antibodies almost always exhibit a weak affinity for their targets, but as the reaction to the antigen continues, these affinities become stronger.
It is well documented that Ni is capable of catalyzing the nucleation and growth of CNFs/CNTs due to a weak affinity for carbon [7 10].
Consequently, yellow brown soil and boggy soil had strong binding capacity for Cd2+ and Zn2+, while paddy soil and yellow drab soil had weak affinity for Cd2+ and Zn2+, resulting in high environmental risk.
