Sentence examples for we therefore targeted from inspiring English sources

We therefore targeted mutations to the A isoform directly, using homologous recombination to generate the fruΔA allele, in which the nucleotides encoding the predicted zinc-finger DNA-binding domain of the FruA specific exon are replaced by nucleotides encoding c- myc epitope tags.

Very high OPA1 levels are, however, toxic, causing paradoxical mitochondrial fragmentation (Cipolat et al., 2004): we therefore targeted, by homologous recombination in the murine X chromosome Hprt region, a transgene-carrying mouse variant 1 Opa1 under the human β-actin promoter (Opa1 tg ).

We therefore targeted this residue as a control and constructed a third plasmid with RNB mutant Dis3 (T808A) fused to GST.

We therefore targeted all three behaviours together – referring to them as 'disclosure of dementia'.

Rheumatoid arthritis (RA) is an archetypal autoimmune disease and we, therefore, targeted putative T1D susceptibility loci for genotyping in UK RA cases and unrelated controls.

We therefore targeted four positively charged residues on the top propeller face, as well as a surface tryptophan, all of which are conserved.

Therefore, targeted destruction of this helicase could be useful for elimination of cancer cells.

Therefore, targeted therapy against neuroendocrine tumors may be more efficient and better tolerated if a cytotoxic targeted compound is combined with another targeted agent with a different toxicity profile.

However, a mortgage modification may be of little help to those who have no job and no steady income - and therefore targeted assistance is needed to help these individuals.

Therefore, targeted inhibition of KLK4 may present an avenue to new treatments for advanced prostate cancer.

Therefore, targeted strategies are needed to be implemented for future therapies to ensure efficient activity at the site of patients' primary tumors or metastases without causing intolerable side effects.