We therefore postulated that these diseases may be inversely associated.
We therefore postulated that this rapid nuclear TFEB translocation following inhibition of mTORC1 suggests a constitutive dephosphorylation of TFEB, which, under normal conditions, is balanced by the constitutive phosphorylation of TFEB by mTORC1.
We therefore postulated that by manipulating the nucleotide backbone and fine tuning the duplex stability through modified nucleotide chemistry, it may be possible to significantly modulate many characteristics of the system, such as binding affinity, specificity, stability, in vitro and cellular activity, which would be crucial for development of efficacious CRISPR-based therapeutic entities.
We therefore postulated that the atypical CnAß was a truncated product of CnAß produced by calpain.
We therefore postulated that both Hans and minorities were recruited for building mausoleum, but many were from South China.
We therefore postulated that the incomplete penetration of the drug may be attributed to a multicellular resistance involving cell contact in spheroids.
We therefore postulated that LRP-1-dependent control of both ERK and JNK pathways contributes to modulate the cell-matrix interaction to support invasiveness.
We, therefore, postulated that perhaps another benefit could be afforded the injured kidney than simply a structural one by the presence of hAFSC during the acute phase of injury.
We therefore postulated that PI3K activation is disturbed in a manner specific for subcellular localization and that in our system Akt phosphorylation at the whole-cell level is an inappropriate indicator of PI3K activity at such an early stage of infection.
We therefore postulated that if pro-inflammatory cells were the source of cathepsin activity and played a causative role in polyposis, then suppression of polyposis-associated inflammation should hinder progressive polyp growth, and this therapeutic effect should be reflected in a significant down-regulation of cathepsin activity.
We therefore postulated that the relevant oxidizing species is NO2.
