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Using in vitro activated T cells from 8 patients and 8 controls we significantly validated the overexpression of SPATS2L (FC = 1.58, p-value = 0.0014) and KLF6 (FC = 1.23, p-value = 0.024) genes in psoriasis.
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We performed target prediction for the 17 significantly validated differentially expressed miRNAs (shown in Table 2) to identify the influence of carnitine supplementation on potential target mRNAs in skeletal muscle of obese Zucker rats by combining the results from three online free available algorithms.
Although the effect of combined goserelin and TAM on DFS and OS in premenopausal patients with stages I and II breast cancer was significantly validated by the Austrian Breast and Colorectal Cancer Study Group Trial 5 (Jakesz et al, 2002), we were unable to determine conclusively whether better DFS and OS were reached because of the small sample size and short follow-up time of our study.
Therefore, only when the comparison was based on a large dataset such as SEER the difference between AJCC-6 and AJCC-7 was significantly validated.
Gene-term enrichment analysis of the targets predicted from the significantly validated most differentially expressed miRNAs using KEGG pathways revealed several enriched regulatory pathways.
Only the 17 significantly validated differentially expressed miRNAs, which were proven significant by qRT-PCR, were used for the subsequent target prediction and functional analysis.> -wrap-foot> *P-values have been corrected for multiple testing by the Benjamini and Hochberg adjustment method.
Significantly, we established and validated a new, sub-lethal biomechanical injury condition for chondrocytes in three-dimensional chondrocyte-alginate constructs.
In this work we clearly validated that ELF-EMF inhibits significantly the development of preneoplastic lesions.
We found and validated three new autoantigens significantly associated with early RA.
By using protein arrays and ELISA assays, we validated three new autoantibodies significantly associated with early RA.
First we validated that Cd68 was significantly upregulated in the spinal cord of SOD/+ mice, but not in SOD/OXR1 animals at Day 90 by quantitative PCR (Fig. 6K and L).
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