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Some of the required revisions will likely require further experimentation within the framework of the presented studies and techniques.
Determining whether MC3R signaling in these neurons is required specifically for the expression of food anticipatory rhythms will require further experimentation; for example, we can use a recently developed inducible MC3R expression model to determine whether MC3R expression in the DMH alone is sufficient to rescue this behavior (Begriche et al. 2011a).
However, confirmation of this hypothesis would require further experimentation, which is beyond the scope of the current study.
This paper brings to light multiple clinical questions that require further experimentation to clarify.
The validity of these proposed mechanisms will require further experimentation.
Rationalization of this in terms of electrostatic networks will require further experimentation.
This may indicate a multi-layered complexity that would require further experimentation to separate.
This implies possibly elevated turnover/repair of PSII, although proof of this would require further experimentation.
However, the exact reasons for these observations are presently unclear and require further experimentation.
Assessment of regulation at the protein level will require further experimentation to differentiate the two gene products.
Confirmation of the PV location and the mechanism of trafficking of the hydroxylase into the PV require further experimentation.
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