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With the aim to develop alternative therapeutic tools for the treatment of resistant cancers, here we propose targeted Pluronic® P123/F127 mixed micelles (PMM) delivering niclosamide (NCL) as a repositioning strategy to treat multidrug resistant non-small lung cancer cell lines.
We propose targeted NGS deafness gene screening in the remaining undiagnosed individuals.
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Motivated by the development of contemporary cancer treatments, we propose targeting three main questions sequentially in order to determine (1) whether a drug is efficacious, (2) whether a biomarker can personalize treatment, and (3) how to define personalization.
In SAH, DFX is proposed to target the toxic end product of RBC lysis, iron, and could act synergistically with IL-1Ra, which we propose targets the inflammatory effects of haem.
We propose targeting IL-15 to deal with some of these limitations, because it is involved in the inflammatory cascade acting as a major stimulus for TNF-α synthesis and because, as just noted, it is involved in the pathogenesis of autoimmune diseases.
In this section, we propose target dictionary estimation from a small-parallel corpus only.
Moreover, as repression of kinase activity is, in many cases, a tractable pharmacologic approach, we now propose targeting GSK3 β activity as a tangible therapeutic strategy for ARMS.
Thus, as there is no standard methods to evaluate household-level medicine access, as defined previously in this review, we propose studies targeted on population access to all medicines, regardless of consumption pattern (chronic or acute).
He proposed targeting the newly bankrupt for offers of credit.
We propose that targeting the stress response is a key factor in identifying connective tissue biomarkers.
We propose that targeting JAK3 offers alternative avenues for the development of new immunomodulatory strategies of therapeutic value.
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