Exact(1)
This finding is particularly interesting because observations in natural settings reveal that gustatory responsiveness remains intact throughout aging in the honey bee, a response we previously replicated in the laboratory using hyperoxia (Rascón et al., in progress).
Similar(59)
This set of experimental conditions enabled us to accurately determine the number of chromosomes in cells in which new DNA replication rounds are halted and previously replicated chromosomes have finished segregating.
H6N2 and H8N4 strains represented two AIV subtypes isolated from poultry and previously replicated to high titers in LMH cells with visual cell damage indicative of a cytopathic effect (CPE) at 48 h post infection (hpi).
Our study confirmed 5 of 5 previously replicated maternal smoking-related CpG sites representing 3 gene regions.
We observed nominally significant associations between CBC and SNPs in three regions previously associated with breast cancer, 10q26 (FGFR2), 8q24, and 2q35, all of which had been previously replicated in studies of UBC [ 20- 28].
The International IBC Lipid Genetics Consortium was also able to verify 49 of the 136 GLGC reported associations, which due to lack of a large enough independent sample were not previously replicated.
One fragment of the cytochrome b was previously replicated in the Ancient Biomolecules Centre (Oxford), yielding the same sequence as in the present study.
Fourth, any genes lacking polymorphisms (coding and non-coding) between parental strains were excluded from analyses, and lastly, positional overlap with a previously replicated major colitis susceptibility quantitative trait locus (Cdcs1) prioritised Tm3 for targeted analysis.
The robustness of gene differential expression is supported by the previously replicated array experiments using two well established and technologically different platforms using RNA from the current samples [ 37].
Although these two SNPs were among the 30 most significantly associated with breast cancer risk in a prior GWAS [ 7], the associations had not been previously replicated in other study populations [ 31].
Thus, because of the timing of genotyping relative to progress in the field, and to a limited extent because of assay design limitations, several previously replicated SNPs could not be included.
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