When getting an answer involved a trip to the library and 22 minutes to answer an average question, we only attempted to get answers to important questions.
In our study, for simplicity, we only attempted fragments of 3-residue and 9-residue.
We only attempted to 'validate' a sample of positive reports of family history of cancer in this study.
As the number of samples with MSI was limited, we only attempted mathematical validation of the two genes as predictors of hereditary MSI.
However, it should be noted that these genes may not represent all the genes affected by the rearrangements, since only the validated SVs were considered here and we only attempted to validate deletions, inversions and translocations that occurred in or near RefSeq genes.
We only attempted to validate SNPs that had flanking regions of at least 18 bp free of other polymorphisms on both sides, so it's possible that the validation rate of 91% is higher than other studies because of this requirement.
This discrepancy may be explained by the selection of rearrangements for validation in this study, since we only attempted to confirm the SVs that occurred in or within two insert lengths of RefSeq genes and within two insert lengths of similar SVs in other tumors.
The one thing we know about him, like everybody else, was that he had a private life, and he had personal feelings which we can only attempt to guess.
The crazy part is that barring a total civilizational meltdown, the prospect of digital telepathy will eventually stop being a prospect we can only attempt to imagine and start being a reality that some of us live.
We will only attempt this analysis if the results of the investigation of heterogeneity do not rule it out and the model diagnostics are acceptable.
