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Our main result is that we now validated that balance testing provides accurate and precise estimates of TA, and hence, also provides an approach towards an automated monitor of sleepiness.
ANXA10 was one of the markers included in the signature and we now validated the prognostic relevance of ANXA10 at the protein level.
We now validated whether [F]FB-IL2 can be used to quantify activated human peripheral blood mononuclear cells (hPBMC) in rats by pharmacokinetic modelling.
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We now validate the predictions of the probability of distinctiveness using the system of drugs of the nervous system.
It is clear that synonyms are used in different ways in different contexts and care must be exercised when using these; we now validate synonyms prior to including these and provide feedback both requesting terms and flagging errors when performing mapping.
However, to address this Reviewer comment, we have now validated that we are seeing the same downstream effects with sorafenib observed previously with erastin, including glutathione depletion (Yang et al (2014) Cell) and lipid peroxidation (Dixon et al. (2012) Cell).
We have now validated several panels of genes that characterise this BRCA1-deficient breast cancer profile.
Per reviewer's request, we have now validated this result using two additional independent Rpl5-targeting siRNAs in yet two independent isolates of primary Rps27l +/+ MEFs from different breeders.
While our initial manuscript was based mainly on functional validations (e.g. number of centrioles for Sas-6 depletion), we have now validated in addition every key siRNA (Mad2, Sas-6, KIF2a and MCAK) by immunoblotting.
Although in principle, such models, mainly using bradykinin alone, have been used before [ 25, 26], we could now validate this model for the assessment of long-lasting antinociceptive effects of a single injection of HA preparations in individual animals.
In addition to the previous observation of some of us that virB expression is Rsh-dependent [ 23], we therefore have now validated by a biological survival assay a second Brucella gene product whose activity was necessary for intramacrophagic and intramurine replication and whose expression was controlled by Rsh during starvation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com