Sentence examples for we next reproduced from inspiring English sources

To determine if the attenuation of CYP3A gene expression predicted by the in silico model occurs in reality we next reproduced the in silico experiments in an in vitro setting: In addition, all components of the in vitro test system (cell line, target gene and PXR regulatory regions) were of human origin, allowing us to examine if the regulatory loop also functioned in the human context.

To evaluate whether morphological alterations and autophagy defects in DAn were mechanistically linked, we next reproduced in Ctrl-iPSC-derived DAn the blockage of autophagic clearance observed in ID-PD and LRRK2-PD iPSC, by inducing autophagosome formation through mTOR inhibition with rapamycin and, at the same time, blocking lysosomal degradation with leupeptin.

We next sought to reproduce the APP-induced LDLR over-expression and mis-localization in a physiologically relevant experimental system an in vivo model of AD.

We live, we reproduce, we die.

We next examined whether these results are reproduced by our system in which the docking calculations were performed by taking a single PDB structure from DFG-in and from DFG-out, generating ensembles, conducting dockings on ensembles with ligands, and extracting maximum values among ensembles for each ligand.

Another S.& P. employee wrote in an instant message the next April, reproduced in the complaint: "We rate every deal.

We next tested whether these results could be reproduced by using an independent dataset.

We next asked the question whether we could reproduce the effects of POH1 depletion on ErbB2 levels by chronic inhibition of proteasome activity.

We next investigated whether the same phenomenon will be reproduced also with decidual NK clones.

We next asked whether reducing SOCS5/6 was sufficient to reproduce the effects of RasV12 on YAP expression and activity.

We next tested whether these in vitro findings could be reproduced in an animal model.