Because the 3 cases we observed might indicate that more migrants and refugees are infected, LBRF should be considered an emerging disease among migrants and refugees.
However, the infection rate we found might indicate an emerging public health problem in many countries; for instance, E. vogeli infections have been documented in a hunter from French Guyana (12 ), in an indigenous human population in the Amazon region of Venezuela (13 ), and in pacas and bush dogs in Argentina (4 ).
Instead, we believe they might indicate interactions in an earlier particle.
We believe this might indicate a lower sensitivity for other influences on health.
When the CvManGO method found a computational prediction paired with a manually assigned 'unknown' annotation, we considered that this might indicate that there is evidence in the literature to support a non-'unknown' annotation, and we therefore reviewed the body of literature for those genes to see if there were annotations missing from our manual set.
We propose that endostatin might indicate the degree of vascular injury in SSc and MCTD patients.
We speculate that this might indicate that the role of CK1 in Rec8 phosphorylation is reduced in haploids, although this remains to be tested.
Further, by querying the Urinary Proteins Biomarker Database we found that some of the proteins differently excreted in this study were also identified as urinary markers of diabetic nephropathy, ureteropelvic junction obstruction and IgA nephropathy therefore we speculated that they might indicate the same injury sites or pathophysiological processes.
We speculate that this might indicate that CG methylation is somehow linked to non-CG modifications, possibly via interactions between the maintenance DNA methyltransferase, Dnmt1, and the de novo enzyme, Dnmt3, both of which are present in bees [ 5], and the bee TET protein.
