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(It is a sobering thought that we might generally tend to overrate censure and underrate praise because of the regression fallacy).
Structurally, given the limited packing of protein loops relative to their interiors, we might generally expect multistate structural behavior of loops, with multiple conformational states explored and mutations affecting the "shape" of the conformational energy landscape, in contrast to a single dominant folded unfolded transition as in a two-state, fully cooperative process.
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The geographic taxon sampling strategy we employed might generally be expected to upwardly bias the support for monophyly, since it does not sample all of the biological complexity of each species and all its relatives across their range.
We might be generally poorer and therefore believe more in social justice and the welfare state, because our parents did not have the advantage of saving the amounts of money that the children of the booming West German economy had.
Alternatively, since previous studies excluded the involvement of HLXB9 in CRS [ 48] and we failed to identify any HLXB9 mutation, we might more generally consider our patient to be a rare case of association between CRS and LPD.
We tested whether Mrs1 might generally be able to bind tetraloop-receptor motifs by evaluating binding to two other RNAs that contain this interaction.
As HDAC inhibition has been shown to restore imprinted tumor suppressors such as CDKN1C in rhabdoid tumors [ 39], we hypothesized that HDACi might generally compensate the missing chromatin remodeling function caused by SMARCB1 loss.
In any case, however, and contrary to the apprehension that with increasing age the amount of non-specific labeling and false-positive marker expression might generally increase, we found a reduction in DCX expression and a reduction in marker overlap.
We speculate that dicer dsRBDs might generally function in nucleocytoplasmic transport and not necessarily substrate binding.
While self-generated expectations might generally involve representing the expected event in the focus of attention in working memory, cues might only lead to such representations under supportive circumstances (i.e., cue of high validity and attended).
Our results on AEP and TTCF processing and presentation in vitro allowed us to propose that a small number of 'unlocking' cleavages by a single protease might generally suffice to generate a substrate for class II MHC capture [59].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com