Although the mioCΔ present in NCM4387, the other strain selected for growth on pyrimidines at high temperature, appeared to be unselected, this same deletion occurred independently in a related strain (the parent of strains NCM4299 and 4300) and hence we believe it may confer some subtle benefit (Table 1; [3]).
A notable structural feature of the human psoriasin/S100A7 gene is a consensus Jab1-binding domain sequence that we have speculated may confer the ability of human psoriasin/S100A7 to interact with Jab1 and so play an important role in the mechanism by which human psoriasin/S100A7 medicates its action [ 6].
We explored whether eHsp90 may confer invasive properties to GBM via regulation of EphA2 mediated signaling.
While we agree that the origin of RNA editing activity itself is clearly a neutral event, we suggest that it may confer some fitness to the organellar genomes.
Based on in vitro studies of Brk overexpression in HB4a mammary epithelial cells [ 33], we hypothesized that Brk may confer a proliferative and/or pro-survival phenotype to normal MEC in vivo.
Because both the serine peptidase and CRN families are highly duplicated in Bd, we reasoned that they may confer important functions and, therefore, investigated the possibility that strong selection has been involved in their evolution.
We hypothesize that this phenomenon may confer evolutionary advantages, in light of the large fluctuations in flagellar numbers within a cell population.
We propose that miR-145 may confer stem cell-like properties on urothelial carcinoma cells and thus facilitate differentiation into multiple cell types.
Given emerging concerns regarding consequences of late prematurity, we speculate that TC care may confer important long term benefits [ 17, 18].
We hypothesized that COMT variation may confer a general risk for psychiatric disorders and have genotyped four COMT variants (Val158Met, rs737865, rs165599, and a SNP in the P2 promoter [-278A/G; rs2097603]) in 394 Caucasian cases and 467 controls.
We reasoned that as cisplatin may confer resistance in multiple ways, the heterogeneity among the biological replicates could possibly reflect a biologically heterogeneous response but it cannot be ruled out that also experimental variations by other means could contribute to the observed results.
