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We indeed identified differentially methylated and hydroxymethylated regions after SD that were enriched in functional pathways involved in neurotransmission, cellular assembly or metabolism.
We indeed identified two different promoter regions for each gene: one mainly involved in the control of rae-1δ gene expression and the other in the control of rae-1ε expression.
Using transcription profiling in transgenic flies that express wt-MYOC and mutants of MYOC we indeed identified genes associated with the UPR, ubiquitination, apoptosis, and oxidative stress characteristic of pathways that can be triggered by ER stress as a consequence of misfolded protein accumulation [35].
We indeed identified two different promoter regions for each gene, one upstream of exon 1, mainly involved in the control of rae-1ε gene expression and a second one, upstream of a previously unknown exon, named exon 3b, mainly involved in the control of rae-1δ gene expression.
We indeed identified up to 13 SLC1s in fish genomes.
We indeed identified a 20 kDa fragment corresponding to the expected size for J1ICD.
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We indeed identify a new mechanism for such waves, based on the interplay between curved membrane proteins of both convex and concave shapes, and give a specific biological example where it may apply.
To demonstrate that we have indeed identified novel cell cycle-regulated chromatin factors, we experimentally validated five novel candidates for cell cycle-regulated chromatin association.
When cdh23 and prestin were used as bait to screen the same OHC-rich cDNA library, we have indeed identified two completely different prey groups associated with prestin and cdh23 respectively.
By analyzing predictions from ReKINect based on cancer mutations identified to hit validated DoS residues (Table S1), in many cases with amino acid substitutions analogous to the ones we experimentally tested above, we could indeed identify additional cancer mutations that with high likelihood cause downstream rewiring.
To obtain experimental evidence that we could indeed identify new markers that enrich for human epidermal stem cells, we explored the expression and function of CD46 (which is also known as membrane co-factor protein).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com