In two independent families with symptoms related to autosomal dominant SCT, we identified – by exome sequencing – two protein-altering variants in the embryonic myosin heavy chain 3 (MYH3) gene.
Moreover, we identified, by engineering the S2 subsite of both recombinant enzymes, two critical residues involved respectively in the kininase activity of cathepsin K, i.e. Tyr67/Leu205, versus kininogenase activity of cathepsin L, i.e. Leu67/Ala205.
Based on the protein sequences of the known erythrose reductases from Trichosporonoides megachiliensis SNG-42 (Ookura et al. [2005]), we identified by in silico analysis candidate proteins for Err1 in T. reesei, A. niger, and F. graminearum.
To date, 12 cases of pancreatic MAEC that met criteria by the WHO classification have been reported in the English literature, which we identified by a PubMed search [3 10].
In this study, we identified by in silico analysis proteins in T. reesei, A. niger, and F. graminearum exhibiting a high sequence similarity to the erythrose reductase (ER1) from Trichosporonoides megachiliensis.
Furthermore we identified, by global gene expression analysis, 26 new target genes influenced by siRNA SOX11 downmodulation.
The genes that we identified by surrogate SNPs are candidates that require additional confirmation in independent samples.
To determine if this was also the case for the binding targets we identified by ChIP-chip, we examined the level of mitochondrial gene expression in microarray data.
KEGG pathway analysis [35] revealed that the Myc direct target genes we identified by ChIP-chip are additionally involved in many previously known and unknown pathways (Table 1).
Here, we report the expression patterns of all 48 PTP genes that we identified by in situ hybridization at six stages of zebrafish development.
Next, we identified by immunofluorescence that CD74 was expressed in cells close to both, the superficial and deep capillary layers in SD rats.
