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We herein identified a unique pathogenic macrophage subpopulation driven by IL-23 with a distinct gene expression profile including defined types of cytokines.
Similarly, we herein identified only two MHC class II multi-locus haplotypes in this species, suggesting that some MHC haplotypes may have been lost through the known bottlenecks, perhaps at times when permissive conditions might have caused the MHC loci to act like neutral loci.
Furthermore, a recent work did suggest some association in two loci for which we herein identified a nominal association but not reaching significance after multi-test correction as we observe for DDX6 rs7130875 and IL12A rs77583790 [ 12].
While we had previously shown that the PRE interacts with nuclear proteins in a tissue-type specific manner, we herein identified TFs that were likely bind to the PRE, specifically activator protein 2 (AP2), nm23 nucleoside diphosphate kinase/metastatic inhibitory protein (PuF), and specificity protein 1 (SP1).
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Consistent with a notion that the transcription rate of cirp is increased at moderately low temperatures, we have herein identified a MCRE in the 5′ flanking region of the cirp gene that enhances gene expression at 32°C.
To exemplify this, we have herein identified markers that can be used to classify breast cancer into subtypes consistent with independent means of classification and shown these markers to be prognostic of OS and RFS.
To analyze the microarray data in an integrative manner, we searched for potential known interactions among the herein identified CS/CPB-induced genes.
These nodes are herein identified as the components for an integrated study or second-tier nodes.
The herein identified candidate genes and pathways may provide promising prognostic biomarker and therapeutic targets.
Thus, NK cells were herein identified as CD161bright lymphocytes, based on FITC-conjugated anti-CD161 labeling and scatter properties [48].
However, our herein identified RBPs are generally higher expressed than non-RBPs (p<2×10−6, Wilcoxon test); an observation that has been made previously for conventional RBPs as well [28].
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