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Effective treatment with better prognosis can be achieved if we have a comprehensive understanding of the pathogenesis of the metabolic disorder.
As in vitro and in vivo pre-clinical data continue to emerge around the role of RIP1 kinase in driving inflammation and pathology, it is essential that we have a comprehensive understanding around the biology to inform clinical development efforts.
The true strength of the association can only be estimated by direct association; this can only occur once we have a comprehensive understanding of how all variation affects each gene product.
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In total we reviewed 85 articles and documents; we concluded our review once we felt that we had a comprehensive understanding of the literature and that further research would not lead to new insights.
"We're in the early stages of doing that, and we do not have a comprehensive understanding as of yet of where that oil is," Jane Lubchenco, the NOAA administrator, told Congress on Wednesday.
We failed at containing the 2009 pandemic influenza simply because, among other factors, we do not have a comprehensive understanding of what makes an influenza strain transmissible in humans.
The outwardly obvious reason for this trend is that we do not have a comprehensive understanding of the function of FN genes.
These calculations are made under standard physical conditions since we do not have a comprehensive understanding of the steady state pool size of products and reactants typically found in cells (Table 2).
However, even with this concentrated research effort, we still do not have a comprehensive understanding of how N-cycling microbial communities in subtropical plantations respond to N and phosphorus (P) additions.
Unfortunately, we do not currently have a comprehensive understanding of how Wnt-5a brings about its effects.
Despite significant improvements in our understanding of the pathogenesis of HCC over the past few decades, we still do not have a comprehensive understanding of the major molecular pathogenic processes involved in liver carcinogenesis.
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