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The dataset we generated upon specific immunoprecipitation of Fmrp (Fig 3 and Supporting Information Table S5) suggests that FMRP acts as a master regulator of a large subset of mRNAs involved in multiple steps of cancer progression including invasion and intravasation: two of the several steps in tumour progression.
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For the single species sequence sets we generated shuffled motifs, based upon the KR motif, as a control to search across the same sets.
We generated 500 model replicates based upon different combinations of vital rate values for each of nine scenarios, where scenarios represented different combinations of reduction in survival and level of correlation among vital rates.
To determine whether this pErk signal is dependent upon EGFR, we generated FSC clones that are homozygous for Egfr f24, a loss-of-function allele, and stained for pErk.
All told, wherever that starting point is, the point is to drive us out to spread the good news that we do not have to be captive to injustice we generate, enacted upon us, or on our behalf.
Indeed, all but one (G117W) of the mutations of p53 that we report here to be generated upon nutlin-3 adaptation have been previously found in patient biopsies and established cancer cell lines (see http://www-p53.iarc.fr/), confirming that the continuous treatment with nutlin-3 confers a strong selection pressure against functional wild-type p53.
To determine whether ROS generated upon treatment with LacCer is critical in cardiac hypertrophy, we examined the effects of NAC and DPI on hypertrophy in H9c2 cells.
In time, he will add 15 to 20 pounds to his 200-pound frame to better control the shuddering energy generated upon planting a fiberglass and carbon-fiber pole into a box while running at sprinter's speed.
Insets show the forces generated upon approach at short separation distances.
It depended on the product's rheological properties and the quantity of steam generated upon decompression.
Nitrate-reduction products generated upon prolonged electrolyses at different potentials were quantified.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com