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We recognize that these mutations might also exhibit impaired interactions with other integrin binding proteins, and therefore we generated a number of mutants to reveal a general picture of the functional role of skelemin integrin interactions.
Using this approach, we generated a number of semisynthetic prenylated Rab GTPases.
By synthesizing and self-assembling of a series of long-chain fatty acids derivatives of 2,6-diaminopyridine and 2-aminopyridine, we generated a number of products ranging from nanosheets, fibers to tubes.
The sampling process has been set up as follows: first we generated a number of random user-IDs, lying in the interval [ 0, 2 32 − 1 ], equal to the dimension of the BFS-sample multiplied by 8.
We generated a number of bait and prey plasmids as described above and in the Supporting Information.
To map the signals required for FGFR4 activation, we generated a number of chimeric constructs between FGF19 and FGF21 using conserved residues to form junctions (Fig. 2B).
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Furthermore, we generate a number of different neural network recognizers by changing the initialization parameters.
Hole scenario: for a given range image RI we generate a number of replicas RI holes k, with k∈[1,4].
Noise scenario: for a given range image RI we generate a number of replicas RI noise k, with k∈[0,10], where each replica is smeared with Gaussian noise with zero mean and standard deviation σ=k·Δs, where we set Δs equal to the average grid spacing.
We have generated a number of designed protein protein interfaces with very favorable computed binding energies but which do not appear to be formed in experiments, suggesting that there may be important physical chemistry missing in the energy calculations.
Using a forward genetics approach, we have generated a number of novel mutant alleles that are linked to disturbed morphogenesis during development.
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