We explore over-diagnosis and initial risk difference as possible explanations for the observations from the MLP, as well as the potential effectiveness of using more sensitive screening technologies.
For this reason, we explored over-represented genes whose molecular or cellular functions seemed to be more influenced by ASR1 a priori, for example, those encoding cell wall proteins and aquaporins (AQP), which are related to the physiological response to limited water accessibility [ 33].
We explored over 40 variables, of which only 12 emerged as significant.
Over four seasons, Fringe has gradually shifted away from "monster of the week" cases to explore over-arching themes and its own mythology.
We did further sensitivity analysis using bootstrap resampling techniques, with 1000 iterations, of the univariable analysis and of the multivariable models at all steps, to explore over-optimism of the variable selection processes used.
We explored whether over-expression of PHB inhibited apoptosis through activation of the MEK-Erk-signaling pathway.
First, we explored whether over-expression of PHB prevented apoptosis at the mitochondrial level by inhibiting mitochondrial cytochrome c release to cytosol and concomitant activation of down-stream caspase-3, as part of the anti-apoptotic mechanism.
Analysis of the chromatin structure deposited on the transgene could then be easily explored over the GFP sequence that is unique in the genome.
Next, to help describe changes in equity in the use of institutional-based delivery, we explore changes over time in the extent to which poor women relied on the private institutional sector for delivery care.
For countries with generalized epidemics, we explore if this relationship has changed over time.
In this paper, we explore the relevance of over-diagnosis and initial difference hypotheses with a microsimulation approach, as well as the relevance of two screening parameters: test sensitivity and systematic negative error.
