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How do we dose novel targeted drugs in patients with renal or hepatic failure undergoing SLEDD (sustained slow-efficiency dialysis) or MARS (Molecular Adsorbents Recirculation System) treatment?
Eight patients required dose delays (38%), predominantly because of neutropenia; however, we dose delayed patients rather than administer granulocyte-colony stimulating factor (G-CSF).
In general, we dose fenoldopam infusion at 0.09 μg/kg/min and wean off when there is resolution of AKI as evidenced by SCr returning to baseline.
Borrowing this concept from the field of oncology, we dose escalated cyclophosphamide, the most effective antilupus medication, to 200 mg/kg.
Hence, we dose normalized all noise values to a reference of 8.0 mGy and employed this to calculate CNRD and SNRD data (Fig. 3, Table 3).
Similar(55)
That is why we dosed our bees in the lab, before putting them in the field.
We give actual thought as to how we're feeling, how much we've dosed and when the last time we dosed was.
We dosed DKK-1 serum level in CaP patients and healthy controls.
We dosed NT-Pro-BNP, TnI, procalcitonin and C-reactive protein at admission to the ICU.
We dosed rats by oral gavage for 4 consecutive days with each individual chemical to establish dose effect functions.
We dosed serum IGFBP-1 in samples of patients with sepsis and compared it with glycemia and serum C-peptide.
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