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"When we demonstrated at trade shows, we were mobbed".
In this manner, we demonstrated at atomic level that PAMAM-NH2, unlike PAMAM-OH, could form a well-compacted complex with asODN, albeit PAMAM-OH can also establish stable interactions with the oligonucleotide.
Considering primary outpoints as percentage of responders, we demonstrated at least 50 % reduction of monthly migraine attacks and migraine days in respectively 81 and 75%% of patients, between run-in and 60-days of treatment (see Fig. 2).
In fact, the presence of hypoxic foci with expression of CAIX was an independent worse prognostic factor for PDC patients (Supplementary Table 1) that we demonstrated at first time using large series of cases.
In conclusion, we demonstrated at both the mRNA and protein levels that biochanin A inhibited the expression of MMP-1, −3, and −13 and increased the expression of TIMP-1, all of which are classic biomarkers of inflammation and cartilage degradation in OA.
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Here we demonstrate at least two, and possibly three, subpopulations of cynomolgus macaques on Mauritius.
It is possible that tnnt2 knockdown does reduce dll4 expression at 38 hpf, but this is followed by the up-regulation we demonstrate at later time points.
Among the primed CTLs, we demonstrate at least three specificities against the known shared breast tumor antigens cyclin B1, MUC-1, and survivin.
We demonstrate at the 12 hours time point used in the migration assay that there was no change in cell cycle upon platelet addition (Additional file 4: Figure S4) and thus we speculate that platelets increase the migration of ovarian cancer cells through chemoattraction.
We also demonstrated at least 50 % reduction of monthly migraine attacks and migraine days in respectively 81 and 75%% of patients.
In this work, we have demonstrated at an enzymatic level that TFV is activated in a tissue-specific manner.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com