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We hoped we could counteract some of the negative feelings.
We predicted that if we performed the assay with excess P-GTP and no unlabeled GTP, we could counteract the effect of decreased nucleotide affinity by allowing for dissociation and re-association of radiolabeled GTP.
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We hypothesize that geniposide could counteract the negative effects of exendin (9 39) by upregulating TCF7L2 and GLP-1R, which can enhance the activation of GLP-1R downstream pathway.
In transfection experiments, we demonstrated that OTULIN could counteract cellular LUBAC responses, suggesting that OTULIN helps to balance the amount of Met1-polyUb in cells.
As Aβ prevents NGF-induced tyrosine phosphorylation and the subsequent degradation of I-κBα [ 12], we asked whether TGFβ1 could counteract the noxious effects of Aβ by activating NF-κB after having promoted serine phosphorylation of I-κBα.
We next investigated whether DACT1 could counteract Wnt/β-catenin signaling for its tumor-suppressive function.
Because progesterone has antagonistic effects on the estrogen-induced proliferation in mouse uterus (Carson et al., 2000), we also checked whether progesterone could counteract estrogen-induced Ltf expression in ovariectomized mouse uteri.
We therefore asked if Ir-LBP could counteract the anti-apoptotic effects of LTB4.
Next we sought to evaluate whether zinc could counteract hypoxia-induced HIPK2 downregulation and affect HIPK2 binding to chromatin.
First we examined whether AA and A2P could counteract the effect of the PHD inhibitor ethyl 3,4-dihydroxybenzoate (EDHB).
We tested, therefore, whether cAMP agonists could counteract the DNR-induced death both of NB4 cells starting to undergo differentiation with ATRA, and of the ATRA-resistant sub-clones NB4-LR2 and NB4-LR1.
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CEO of Professional Science Editing for Scientists @ prosciediting.com