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It was only when we moved from being hunter-gatherers to agriculturists about 8,000 years ago that we could accumulate enough grapes for winemaking to begin.
In 1970 technological and other experts had prophesied widespread famine in India, but for us it was a year of plenty, when our new agricultural policy bore abundant fruit and we could accumulate a buffer stock of nine million metric tons of grain.
"Education was the only wealth we could accumulate while in exile," says Chet Nath.
Using this approach, we could accumulate most of the cells in mitosis over a short time-course after nocodazole addition.
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Although Fe deficiency can be induced by adding the Fe2+ chelator ferroZine to the growth medium, we elected to use Hoagland's medium with washed agar, as we discovered that ferroZine could accumulate in plant tissues (see Supplementary Figures 1 and 2 for details).
We found that rotenone could accumulate in the subcutaneous adipose tissue because of its lipophilic nature, which might, in part, explain the variation in susceptibility among the animals.
Based on these calculations, we estimated that weanling rats could accumulate approximately 1.75 2 μg Hg by PND45 and approximately 8.5 10 μg Hg by PND90.
Notably, we observed that treatment of MG132 could accumulate ZNRF3-ΔRING protein abundance similar to wild-type ZNRF3 (Fig. 1A), suggesting that the protein stability of ZNRF3 is regulated by E3 ligase(s) other than itself.
As each passage could accumulate more expression changes, we tested if the functional changes previously described were more pronounced after a higher number of passages.
Alternatively, we hypothesized that metabolites derived from the GABA-shunt could accumulate in ssadh mutants and be lethal to cells by causing ROIs accumulation [26].
We hypothesised that breast tumours with TP53 mutations could accumulate genetic alterations leading to complete tumour response through mitotic catastrophes and tumour cell death (Huang et al, 2005).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com