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As we have shown a perinuclear aggregation of both PKCε and vimentin under galectin-1 depletion that is similar to the vesicular aggregation of these two molecules seen by Ivaska et al under inhibition of PKCε activity that, in their study, lead to decreased integrin recycling, we can implicate galectin-1 in mediating the PKCε vimentin-controlled integrin-β1 recycling PKCε vimentin-controlled
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To go beyond diagnosing translational selection and attribute adaptive features of gene anatomy to specific error processes, we need to develop critical tests that can implicate one type of error to the exclusion of others.
If a retired baseball player can implicate the entire sport with steroid charges, if a whistle-blower can rattle the F.B.I., how might just one disaffected ref ravage the N.B.A.'s competitive image?
"They want a veto in sensitive foreign policy issues, including on Israel and Iran — any policy that can implicate the country in a foreign confrontation.
Such tasks are not only sensitive but can also shed light on the specific nature of the dysfunction, and they can implicate dysfunction of specific neural systems, information which can be used to design therapeutic interventions.
Overall, although more compounds should be tested and analyzed for clear SAR against topoisomerase I and cathepsin B and L, compound 15 showed consistent inhibitory ability on the tested assays, which can implicate the cytotoxic activity of compound 15 on topoisomerase I and cathepsin B and L inhibitory pathways.
This last point is crucial, as point mutations lead to all classes of mutations (e.g., null, hypomorphs, neomorphs, antimorphs, and hypermorphs), which is why forward genetic screens can implicate a gene in a particular process when a targeted deletion may not.
In essence, the courts recognize that a statement that is uttered without contemplation or forethought, extemporaneously in the moment, should be considered at trial because people are known to say things impromptu that can implicate them.
Furthermore, proteins that participate in several pathways can implicate multiple biological processes with a single ADR.
At microscopic level, this can implicate the participation of this mechanism in the tumor microvasculature.
Tree edits induced by an SPR operation can implicate lineages that are separated by any number of internal branches.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com