Explain that decisions sometimes become cloudy, and signals become unclear when we are impaired.
While our data suggested that we were impairing glycolytic metabolism, we discounted energetic impairments as a cause for the observed pathogenic impairments since ATP levels were not consistently lower in INPP1 knockdown SKOV3 and C8161 cells (Supplementary Table S1).
With these observations in mind, we asked whether the natural Hsp90 mutants we study here are impaired in their ability to buffer cryptic variation that can be revealed by inbreeding.
In addition, we demonstrate that these strains are impaired for H2O2-induced mutagenesis (Fig. 3).
Therefore, we speculated that MZ7 cells are impaired in MMR.
In this study, we observed that FES patients are impaired in executive attention but not in alerting or orienting attention.
In this study, we showed that autophagy levels are impaired in CD8+ T cells from aged mice.
We showed that d6pk mutants are impaired in basipetal auxin transport in inflorescence stems and postulated that PINs may be directly activated by D6PKs.
More specifically, we found that patients who are impaired by left-hemisphere stroke are facilitated on the right (contralesional) M1 during action observation of hand-object interactions.
If any one of the antioxidant enzymes (table 7) is missing or impaired or any combination of them are impaired, then we would expect to see a similar event as in the knockout mouse model.
