Indeed, we also sensitized established tumor cells when senescence was induced by chemotherapy within a population of same cancer cells.
As JNK and Bim seem to be involved also in TRAIL-induced sensitization to chemotherapeutics in hepatocellular carcinomas, we wondered whether TRAIL could also sensitize primary human hepatocytes to doxorubicin-induced apoptosis.
Crucially, we show that doxorubicin can also sensitize TRAIL-resistant primary breast tumour explants to TRAIL-induced apoptosis, while having no effect on normal breast tissue.
Here we showed that the reduction of RB expression can also sensitize GBMs and GSCs to VP-16-induced apoptosis, demonstrating that RB anti-apoptotic function is still maintained in these tumor cells.
Therefore, to inform educators and researchers, but also sensitize and guide stakeholders in an area that this topic has received little attention, we conducted a large-scale investigation in 17 dental schools in Colombia.
Importantly, XIAP inhibitors also sensitize primary cultured glioblastoma cells derived from surgical specimens as well as glioblastoma-initiating stemlike cancer stem cells for γ-irradiation.
On the other hand, evidence has established that the TRPV1 and TRPA1 channels also sensitize each other in a Ca2+-dependent signaling pathway.
Release of CGRP serves the central transmission of sensory information, initiates local tissue reactions and may also sensitize the nociceptive pathway.
Interestingly, the lysosomal changes associated with immortalization and transformation of cancer cells also sensitize cancer cells to programmed cell death pathways involving lysosomal membrane permeabilization [5], [6].
Surprisingly, through unknown mechanisms, IGFBP3 could also sensitize cells to the phosphorylation of AKT by IGFs, which leads to AKT activation [79], [80].
