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We also commented a key difference between passive tumor targeting and the EPR effect in tumors, particularly as related to drug retention in tumors: passive targeting of low-molecular-weight X-ray contrast agents involves a retention period of less than a few minutes, whereas the EPR effect of nanoparticles involves a prolonged retention time days to weeks.
We also commented on the similarity to other protein structures and added a figure supplement showing a side-by-side comparison of the TCP domain and the closest structural match in the PDB.
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We also comment on the future directions of this technology.
We also comment on other aspects of the report which require clarification.
In this article, we also comment upon the current situation with respect to NP toxicology (nanotoxicology).
We also comment on the numerical methods used to infer these models for each application.
We also comment on the specific criticism to [ 3] in [ 5] and outline the foundations of the correct methodology.
Within this discussion, we also comment on how current PRMs may be used as performance measures.
Later on, we also comment on the choice of these fixed parameters.
We also comment on the potential of causal ordering for emerging applications in large-scale hypothesis management and analytics.
We also comment on the possible application of our results to event generation in high-energy physics simulations.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com