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We additionally required the median FC to be greater than 1 with respect to each of the 9 datasets included in our analysis (PP-increased DEGs) or less than 1 with respect to each dataset (PP-decreased DEGs).
Considering the particular feature of coding sequences, we additionally required that the random x-mers should have the same distribution of frame positions (±20%) with real miRNA x-mer seeds.
To ensure the quality of the data included, we additionally required that outcome ascertainment was made through cancer registry linkage.
All loci that passed these criteria were considered likely miRNA candidates, but for a locus to be considered a reliable de facto miRNA we additionally required that perfect matching reads were observed in at least two tissues.
Second, for the third reference cohort (References 3), we additionally required all participants to have had at least one healthcare consultation in the same year as the case had its neck-injury diagnosis (table 1).
We additionally required junctions to be identified by at least two independent read pairs in one library and either (i) to be present in more than one of the three libraries sequenced or (ii) to correspond to a copy number step, in the SNP6 array-CGH data [ 27] or the array painting data [ 8].
Similar(51)
For broadband imaging, we additionally require that the image sensor has multiple spectral channels, one of which corresponds to the design wavelength of the diffractive optical elements.
Even more stringent bounds apply in some cases if we additionally require a certain amount of sensitivity to initial conditions.
Therefore we additionally
We additionally require that selected proteins do not have paralogs in studied organisms.
To describe the dynamic variation of the fluxes, we additionally require the assumption of specific functional forms that can capture the temporal behaviour.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com