They clearly demonstrated that PTHrP possesses a double signalling on MCF-7: an antimitogenic pathway mediated by the membrane receptor and a second wave of signalling, pro-proliferative and antiapoptotic, based on nuclear localisation of the peptide.
Whether these represent coordinated waves of signaling from monocytes to B cells during this early activation of transplant immunity will have to be tested.
These data suggest that β-arrestin binding, which terminates receptor G protein coupling, also initiates a second wave of signal transduction in which the "desensitized" receptor functions as a critical structural component of a mitogenic signaling complex.
… When the foot touches the ground, there is a wave of signals that are generated, and they are delivered to the arms of the subject through a shirt that contains small mechanical vibration devices.
Finally, this primary activation and aggregation step is followed by a second wave of signals that lead to stabilization of the platelet aggregate [2].
Our data strongly support the view that resistance in Vitis riparia is a post-infection phenomenon, characterized by a rapid wave of signal transduction (12 hpi) followed by a shift in primary and secondary metabolism (24 hpi) to implement a defense mode.
During the earliest stages of signaling, wave periodicity is 6 10 min, depending on the strain and growth conditions.
The attack last month and a wave of arrests signaled a return to the tough policies that were in place before Mr. Razali began his visits.
In the course of our analysis of the BMP signaling pathway, we observed a transient wave of Smad1/5/8 signaling in the inner nuclear layer at the end of the first postnatal week, from postnatal day (P) 5 to P9, after the end of neurogenesis.
This is because it analyses the response waves of signal transduction instead of individual reaction kinetics [ 13- 15, 17- 20].
