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Exact(33)
In genotyping multiple lesions of different stage from the same patient/specimen, we found considerable heterogeneity; most notably, in 12 specimens the proliferative lesion was PIK3CA mutant but the concurrent carcinoma was wild type.
The EGFR gene was wild type.
For the two lesions in the >50 Gy cohort that did not respond significantly, one of which was wild type and the other mutant RAS, none of the derived prognostic factors could correctly predict this outcome.
The KCNJ11 sequence was wild type.
Ten colonies were randomly picked and sequenced; 9 clones were mutant, and 1 was wild type.
The healthy brother was wild type for detected mutations (data not shown).
Similar(25)
The F1 was wild type (non-glabrous).
In our hands, expression of this Arm transgene in embryos had no visible effect when endogenous arm allele was wild-type.
In one mutant, the Uba2 catalytic Cys177 was mutated to Ala to prevent formation of a Uba2∼Sumo intermediate, but the ufd was wild-type.
When the donor was wild-type β2AR-Rluc8 and the acceptor was binding-defective β2AR D113S-V, isopreliablyl relinducednduced a significant BRET decrease (to 0.15±0.01; P<0.001, paired t-test).
In contrast, in five cell lines in which PTEN was expressed, HER2 levels were low, and PIK3CA was wild-type, levels of Akt phosphorylation were low (Figure 1A and Figure S1).
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