Or as Mr. González Iñárritu put it, "Javier had to find a balance while surrendering totally to a role that required him to be completely charged up while showing very little, and that, emotionally, is very arduous".
It's very arduous and, toward the end, you can see that it's taken a toll on everybody.
This has been very arduous, but thanks to odd jobs and help from my family and friends I have somehow survived.
As we all know, the binding assays for CXCR4 with [I]SDF-1α are very arduous and not at all user-friendly, especially with respect to dealing with harmful radioactive materials.
It will be very arduous, if not impossible, to inform patients or consumers beforehand in detail on all relevant aspects for so many diseases without inducing information overload and therewith foregoing the actual aim of informed consent [ 45].
So it was a very arduous process, it was very heavy going.
"It was very long and arduous".
"It's been a very arduous, tough four years," said Alexander Corbluth, principal of the High School of Environmental Studies in Manhattan.
That's still possible, but it's still very arduous, too, and there's even less reason to bother now.
It is very difficult and arduous to create and sustain a democracy - but history shows that closing one down is much simpler.
