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While the levels of serum S-100β have been proposed as a marker to help prognosticate the extent of brain damage in patients suffering anoxic ischemic coma, the PROPAC study was unable to validate a cut-off value for this marker [ 13, 21].
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"Procedural validity" is the appropriateness of the procedures used in standard setting, with poor procedure casting doubt on the validity of a pass mark but good procedure alone being unable to validate a pass mark.
His comments came on the same day that the Pentagon's chief spokesman, Lawrence Di Rita, told reporters that the Defense Department had been unable to validate the assertions made by an Army intelligence veteran, Lt. Col. Anthony Shaffer, and now backed up by Captain Phillpott, about the early identification of Mr. Atta.
For our global work (see the 2010 Environmental Performance Index EPII) and the forthcoming 2012 EPI) it is true that we were unable to validate all data sources (especially those derived from official UN publications – which are becoming fewer in number); but in our recent work with countries we have sought to achieve a higher standard.
However, we were unable to validate these candidate CNVs using real-time PCR-based TaqMan CNV assays.
We were unable to validate the questionnaire responses with peak expiratory flow record data attempted on a 1/3 sample of the workers.
The latter might not be needed using the approach of Reilhac et al. based on its fundamental properties, but we were unable to validate this.
Even though the organization said it had collected enough signatures to get its initiative on the ballot, the effort could falter if county officials are unable to validate enough of the signatures.
We did not find peptides unique to xSENP1b, and so were unable to validate its expression.
Hence, even though we were unable to validate this potential biomarker of SCI severity by WB, we feel that this protein needs to be investigated further, with more extensive sample pre-fractionation prior to quantification.
We were unable to validate KLP59D knockdown by western blot analysis as we lacked specific antibodies to the protein and have not yet generated KLP59D-GFP constructs which could be used for western blotting.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com