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She required a >50% dose reduction of capecitabine and epirubicin and was treated off-study after cycle 4 due to the delays of treatment.
Currently, our patient was treated (off-study) with high dose chemotherapy combining cisplatin with cytosine arabinoside and dexamethasone with addition of Rituximab (R-DHAP).
They said they had received a report of Munchausen abuse: someone at the Children's Hospital of Eastern Ontario, where Katerina had been treated off and on, was concerned that Nicola was subjecting her daughter to unnecessary medical interventions, including surgery.
Patients could also withdraw from the protocol at any time for any reason and be treated off study.
The purpose of this observational study was to analyze the rates, characteristics and associated risk factors of severe infections in patients with systemic autoimmune diseases (SAD) who were treated off-label with biological agents in daily practice.
After being treated off court for a back strain, Davenport returned, clearly in pain and distressed.
My father is one such patient and is being treated off label with Avastin for a glioblastoma.
If patients required a delay of longer than 2 weeks, they were treated off the protocol.
Sixty patients were treated within one of the two randomised trials and 46 patients were treated off trial.
All patients either took part in a single-institution clinical trial, which was approved by the ethical committee, or were treated off study according to the standard arm of the trial.
All patients had received neoadjuvant treatment at the Netherlands Cancer Institute between 2004 and 2013 as part of ongoing clinical trials, or were treated off protocol according to the standard arms of one of these studies [ 6] (NCT01057069, NCT01057069).
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