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This binding was traditionally studied in isolation, despite the fact that many well-studied TFs were known to bind cooperatively to DNA by forming well-defined dimers or (in some cases) higher-order complexes.
Tissue-selective expression was traditionally studied at the single-gene level with time-consuming techniques such as Northern blot and in situ hybridization.
The phylogenetic distribution of isochores was traditionally studied by centrifugation techniques [ 7- 11], but the analysis of base composition at third codon position or the comparison of GC content between coding and non-coding sequences [ 12- 17] has been also used.
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This model has been traditionally studied in complete graphs.
This phenomenon is traditionally studied as a kind of imperfect column buckling problem.
Oxygen reduction reaction (ORR) is traditionally studied on electrodes of large surface covered with a layer of catalysts.
The dynamic behavior of large power systems has been traditionally studied by means of time-varying phasors, under the assumption that the system is quasi-static.
Aristotelian texts were traditionally studied according to the commentaries by Averroes (which provided the internal partition of the texts into sections).
Compound generalization and dimensional generalization are traditionally studied independently by different groups of researchers, who have proposed separate theories to explain results from each area.
Structures of dynamic metamorphism have been traditionally studied proceeding from their similarity with faults, according to stratigraphic criteria and with reconstructions of predeformation settings.
While cell migratory behavior has been traditionally studied using simple assays on culture dishes, in recent years it has been increasingly realized that the physical, mechanical, and chemical aspects of the matrix are key determinants of the migration mechanism.
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CEO of Professional Science Editing for Scientists @ prosciediting.com