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Therefore, while combinatorial treatment in Schedule III was least effective in limiting BrdU incorporation, it was this regimen that proved most effective in limiting cell number over time.
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In this study, NACT based on the PF regimen was investigated; this regimen was also adopted for NACT in a phase III trial that compared NACT+CCRT with CCRT+AC in locoregionally advanced NPC and recently published preliminary results [ 10].
Our conclusion is that this regimen is excellent palliation for metastatic disease and possibly useful neoadjuvant treatment.
Still by 2011, 674 (36.5%) patients of this cohort were receiving this regimen but prescriptions were declining from a maximum of 1080 (61.4%) since 2009 (p for trend <0.001).
Another justification for this dose is that this regimen has the potential to be adapted to daily practice.
They found that fewer than half of the patients were on this regimen before having the procedure.
Several ongoing trials in both the metastatic and adjuvant setting are investigating this regimen further.
Although response rates achieved using MVAC have been encouraging, this regimen has significant toxicity, particularly in older patients.
It is noteworthy that this regimen was also active in patients with 5-fluorouracil or cisplatin-resistant disease.
This is the regimen we plan to use for the proposed trial.
The boy was started on this regimen, and two years later, he is doing well.
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